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Storb, Ursula

One or more keywords matched the following items that are connected to Storb, Ursula

Item Type	Name
Concept	Immunoglobulin Heavy Chains
Concept	Immunoglobulin gamma-Chains
Concept	Immunoglobulin J-Chains
Concept	Immunoglobulin alpha-Chains
Concept	Immunoglobulin lambda-Chains
Concept	Immunoglobulin mu-Chains
Concept	Immunoglobulin kappa-Chains
Concept	Immunoglobulin Light Chains
Academic Article	PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.
Academic Article	N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
Academic Article	Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.
Academic Article	Gamma 2b provides only some of the signals normally given via mu in B cell development.
Academic Article	Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
Academic Article	B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
Academic Article	The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
Academic Article	Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
Academic Article	Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
Academic Article	A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
Academic Article	Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
Academic Article	Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
Academic Article	A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
Academic Article	Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
Academic Article	Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
Academic Article	Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
Academic Article	Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
Academic Article	Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
Academic Article	Factors affecting the rearrangement efficiency of an Ig test gene.
Academic Article	A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
Academic Article	Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
Academic Article	Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
Academic Article	The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
Academic Article	Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
Academic Article	Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
Academic Article	Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.
Academic Article	Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
Academic Article	Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
Academic Article	Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
Academic Article	Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
Academic Article	Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
Academic Article	Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.
Academic Article	Sequences related to immunoglobulin kappa chain messenger RNA in T cells.
Academic Article	Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
Academic Article	Somatic mutation of immunoglobulin light-chain variable-region genes.
Academic Article	Association of two different repetitive DNA elements near immunoglobulin light chain genes.
Academic Article	lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
Academic Article	Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
Academic Article	Transgenic mice with immunoglobulin genes.
Academic Article	The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
Academic Article	Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.
Academic Article	Heterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA.
Academic Article	Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
Academic Article	Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
Academic Article	RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.
Academic Article	Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.
Academic Article	Evolution of mouse immunoglobulin lambda genes.
Academic Article	Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
Academic Article	Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
Academic Article	Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.
Academic Article	Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
Academic Article	Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
Academic Article	Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
Academic Article	The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
Academic Article	The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
Academic Article	The transcription factor Spi-B is not required for somatic hypermutation.
Academic Article	The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
Academic Article	Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
Academic Article	High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
Academic Article	Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
Academic Article	Pre-B cells in kappa-transgenic mice.
Academic Article	High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
Academic Article	Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
Academic Article	Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
Academic Article	Why does somatic hypermutation by AID require transcription of its target genes?

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Immunoglobulin J Chains